Signal-transduction cascades as targets for therapeutic intervention by natural products.
Identifieur interne : 001A70 ( Main/Exploration ); précédent : 001A69; suivant : 001A71Signal-transduction cascades as targets for therapeutic intervention by natural products.
Auteurs : M E Cardenas [États-Unis] ; A. Sanfridson ; N S Cutler ; J. HeitmanSource :
- Trends in biotechnology [ 0167-7799 ] ; 1998.
Descripteurs français
- KwdFr :
- Androstadiènes (pharmacologie), Animaux (MeSH), Antienzymes (pharmacologie), Apoptose (effets des médicaments et des substances chimiques), Benzoquinones (MeSH), Biosynthèse des protéines (MeSH), Calcineurine (métabolisme), Champignons (effets des médicaments et des substances chimiques), Champignons (métabolisme), Ciclosporine (pharmacologie), Cycle cellulaire (effets des médicaments et des substances chimiques), Humains (MeSH), Immunosuppresseurs (pharmacologie), Lactames macrocycliques (MeSH), Protéines du choc thermique HSP90 (effets des médicaments et des substances chimiques), Protéines du choc thermique HSP90 (métabolisme), Quinones (pharmacologie), Sirolimus (pharmacologie), Tacrolimus (pharmacologie), Transduction du signal (effets des médicaments et des substances chimiques), Wortmannine (MeSH).
- MESH :
- effets des médicaments et des substances chimiques : Apoptose, Champignons, Cycle cellulaire, Protéines du choc thermique HSP90, Transduction du signal.
- métabolisme : Calcineurine, Champignons, Protéines du choc thermique HSP90.
- pharmacologie : Androstadiènes, Antienzymes, Ciclosporine, Immunosuppresseurs, Quinones, Sirolimus, Tacrolimus.
- Animaux, Benzoquinones, Biosynthèse des protéines, Humains, Lactames macrocycliques, Wortmannine.
English descriptors
- KwdEn :
- Androstadienes (pharmacology), Animals (MeSH), Apoptosis (drug effects), Benzoquinones (MeSH), Calcineurin (metabolism), Cell Cycle (drug effects), Cyclosporine (pharmacology), Enzyme Inhibitors (pharmacology), Fungi (drug effects), Fungi (metabolism), HSP90 Heat-Shock Proteins (drug effects), HSP90 Heat-Shock Proteins (metabolism), Humans (MeSH), Immunosuppressive Agents (pharmacology), Lactams, Macrocyclic (MeSH), Protein Biosynthesis (MeSH), Quinones (pharmacology), Signal Transduction (drug effects), Sirolimus (pharmacology), Tacrolimus (pharmacology), Wortmannin (MeSH).
- MESH :
- chemical , drug effects : HSP90 Heat-Shock Proteins.
- chemical , metabolism : Calcineurin, HSP90 Heat-Shock Proteins.
- chemical , pharmacology : Androstadienes, Cyclosporine, Enzyme Inhibitors, Immunosuppressive Agents, Quinones, Sirolimus, Tacrolimus.
- drug effects : Apoptosis, Cell Cycle, Fungi, Signal Transduction.
- metabolism : Fungi.
- Animals, Benzoquinones, Humans, Lactams, Macrocyclic, Protein Biosynthesis, Wortmannin.
Abstract
Many bacteria and fungi produce natural products that are toxic to other microorganisms and have a variety of physiological effects in animals. Recent studies have revealed that, in several cases, the targets of these agents are components of conserved signal-transduction cascades. This article looks at the mechanisms of action of five natural products--the immunosuppressants cyclosporin A, FK506 and rapamycin, and the antiproliferative agents wortmannin and geldanamycin. These mechanisms reveal the importance of signal-transduction cascades as targets for therapeutic intervention and the enormous utility of studies of natural-product action in simple model genetic systems.
DOI: 10.1016/s0167-7799(98)01239-6
PubMed: 9807840
Affiliations:
Links toward previous steps (curation, corpus...)
Le document en format XML
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Heitman</name></author></analytic><series><title level="j">Trends in biotechnology</title><idno type="ISSN">0167-7799</idno><imprint><date when="1998" type="published">1998</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Androstadienes (pharmacology)</term><term>Animals (MeSH)</term><term>Apoptosis (drug effects)</term><term>Benzoquinones (MeSH)</term><term>Calcineurin (metabolism)</term><term>Cell Cycle (drug effects)</term><term>Cyclosporine (pharmacology)</term><term>Enzyme Inhibitors (pharmacology)</term><term>Fungi (drug effects)</term><term>Fungi (metabolism)</term><term>HSP90 Heat-Shock Proteins (drug effects)</term><term>HSP90 Heat-Shock Proteins (metabolism)</term><term>Humans (MeSH)</term><term>Immunosuppressive Agents (pharmacology)</term><term>Lactams, Macrocyclic (MeSH)</term><term>Protein Biosynthesis (MeSH)</term><term>Quinones (pharmacology)</term><term>Signal Transduction (drug effects)</term><term>Sirolimus (pharmacology)</term><term>Tacrolimus (pharmacology)</term><term>Wortmannin (MeSH)</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>Androstadiènes (pharmacologie)</term><term>Animaux (MeSH)</term><term>Antienzymes (pharmacologie)</term><term>Apoptose (effets des médicaments et des substances chimiques)</term><term>Benzoquinones (MeSH)</term><term>Biosynthèse des protéines (MeSH)</term><term>Calcineurine (métabolisme)</term><term>Champignons (effets des médicaments et des substances chimiques)</term><term>Champignons (métabolisme)</term><term>Ciclosporine (pharmacologie)</term><term>Cycle cellulaire (effets des médicaments et des substances chimiques)</term><term>Humains (MeSH)</term><term>Immunosuppresseurs (pharmacologie)</term><term>Lactames macrocycliques (MeSH)</term><term>Protéines du choc thermique HSP90 (effets des médicaments et des substances chimiques)</term><term>Protéines du choc thermique HSP90 (métabolisme)</term><term>Quinones (pharmacologie)</term><term>Sirolimus (pharmacologie)</term><term>Tacrolimus (pharmacologie)</term><term>Transduction du signal (effets des médicaments et des substances chimiques)</term><term>Wortmannine (MeSH)</term></keywords><keywords scheme="MESH" type="chemical" qualifier="drug effects" xml:lang="en"><term>HSP90 Heat-Shock Proteins</term></keywords><keywords scheme="MESH" type="chemical" qualifier="metabolism" xml:lang="en"><term>Calcineurin</term><term>HSP90 Heat-Shock Proteins</term></keywords><keywords scheme="MESH" type="chemical" qualifier="pharmacology" xml:lang="en"><term>Androstadienes</term><term>Cyclosporine</term><term>Enzyme Inhibitors</term><term>Immunosuppressive Agents</term><term>Quinones</term><term>Sirolimus</term><term>Tacrolimus</term></keywords><keywords scheme="MESH" qualifier="drug effects" xml:lang="en"><term>Apoptosis</term><term>Cell Cycle</term><term>Fungi</term><term>Signal Transduction</term></keywords><keywords scheme="MESH" qualifier="effets des médicaments et des substances chimiques" xml:lang="fr"><term>Apoptose</term><term>Champignons</term><term>Cycle cellulaire</term><term>Protéines du choc thermique HSP90</term><term>Transduction du signal</term></keywords><keywords scheme="MESH" qualifier="metabolism" xml:lang="en"><term>Fungi</term></keywords><keywords scheme="MESH" qualifier="métabolisme" xml:lang="fr"><term>Calcineurine</term><term>Champignons</term><term>Protéines du choc thermique HSP90</term></keywords><keywords scheme="MESH" qualifier="pharmacologie" xml:lang="fr"><term>Androstadiènes</term><term>Antienzymes</term><term>Ciclosporine</term><term>Immunosuppresseurs</term><term>Quinones</term><term>Sirolimus</term><term>Tacrolimus</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Animals</term><term>Benzoquinones</term><term>Humans</term><term>Lactams, Macrocyclic</term><term>Protein Biosynthesis</term><term>Wortmannin</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Animaux</term><term>Benzoquinones</term><term>Biosynthèse des protéines</term><term>Humains</term><term>Lactames macrocycliques</term><term>Wortmannine</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Many bacteria and fungi produce natural products that are toxic to other microorganisms and have a variety of physiological effects in animals. Recent studies have revealed that, in several cases, the targets of these agents are components of conserved signal-transduction cascades. This article looks at the mechanisms of action of five natural products--the immunosuppressants cyclosporin A, FK506 and rapamycin, and the antiproliferative agents wortmannin and geldanamycin. These mechanisms reveal the importance of signal-transduction cascades as targets for therapeutic intervention and the enormous utility of studies of natural-product action in simple model genetic systems.</div></front></TEI><pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">9807840</PMID><DateCompleted><Year>1998</Year><Month>11</Month><Day>30</Day></DateCompleted><DateRevised><Year>2019</Year><Month>11</Month><Day>02</Day></DateRevised><Article PubModel="Print"><Journal><ISSN IssnType="Print">0167-7799</ISSN><JournalIssue CitedMedium="Print"><Volume>16</Volume><Issue>10</Issue><PubDate><Year>1998</Year><Month>Oct</Month></PubDate></JournalIssue><Title>Trends in biotechnology</Title><ISOAbbreviation>Trends Biotechnol</ISOAbbreviation></Journal><ArticleTitle>Signal-transduction cascades as targets for therapeutic intervention by natural products.</ArticleTitle><Pagination><MedlinePgn>427-33</MedlinePgn></Pagination><Abstract><AbstractText>Many bacteria and fungi produce natural products that are toxic to other microorganisms and have a variety of physiological effects in animals. Recent studies have revealed that, in several cases, the targets of these agents are components of conserved signal-transduction cascades. This article looks at the mechanisms of action of five natural products--the immunosuppressants cyclosporin A, FK506 and rapamycin, and the antiproliferative agents wortmannin and geldanamycin. These mechanisms reveal the importance of signal-transduction cascades as targets for therapeutic intervention and the enormous utility of studies of natural-product action in simple model genetic systems.</AbstractText></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Cardenas</LastName><ForeName>M E</ForeName><Initials>ME</Initials><AffiliationInfo><Affiliation>Department of Genetics, Howard Hughes Medical Institute, Duke University Medical Center, Durham, NC 27710, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Sanfridson</LastName><ForeName>A</ForeName><Initials>A</Initials></Author><Author ValidYN="Y"><LastName>Cutler</LastName><ForeName>N S</ForeName><Initials>NS</Initials></Author><Author ValidYN="Y"><LastName>Heitman</LastName><ForeName>J</ForeName><Initials>J</Initials></Author></AuthorList><Language>eng</Language><GrantList CompleteYN="N"><Grant><GrantID>AI39115</GrantID><Acronym>AI</Acronym><Agency>NIAID NIH HHS</Agency><Country>United States</Country></Grant><Grant><GrantID>AI41937</GrantID><Acronym>AI</Acronym><Agency>NIAID NIH HHS</Agency><Country>United States</Country></Grant><Grant><GrantID>KO1 CA77075</GrantID><Acronym>CA</Acronym><Agency>NCI NIH HHS</Agency><Country>United States</Country></Grant></GrantList><PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType><PublicationType UI="D013487">Research Support, U.S. Gov't, P.H.S.</PublicationType><PublicationType UI="D016454">Review</PublicationType></PublicationTypeList></Article><MedlineJournalInfo><Country>England</Country><MedlineTA>Trends Biotechnol</MedlineTA><NlmUniqueID>8310903</NlmUniqueID><ISSNLinking>0167-7799</ISSNLinking></MedlineJournalInfo><ChemicalList><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D000730">Androstadienes</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D016227">Benzoquinones</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D004791">Enzyme Inhibitors</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D018841">HSP90 Heat-Shock Proteins</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D007166">Immunosuppressive Agents</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D047029">Lactams, Macrocyclic</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D011809">Quinones</NameOfSubstance></Chemical><Chemical><RegistryNumber>83HN0GTJ6D</RegistryNumber><NameOfSubstance UI="D016572">Cyclosporine</NameOfSubstance></Chemical><Chemical><RegistryNumber>EC 3.1.3.16</RegistryNumber><NameOfSubstance UI="D019703">Calcineurin</NameOfSubstance></Chemical><Chemical><RegistryNumber>W36ZG6FT64</RegistryNumber><NameOfSubstance UI="D020123">Sirolimus</NameOfSubstance></Chemical><Chemical><RegistryNumber>WM0HAQ4WNM</RegistryNumber><NameOfSubstance UI="D016559">Tacrolimus</NameOfSubstance></Chemical><Chemical><RegistryNumber>XVA4O219QW</RegistryNumber><NameOfSubstance UI="D000077191">Wortmannin</NameOfSubstance></Chemical><Chemical><RegistryNumber>Z3K3VJ16KU</RegistryNumber><NameOfSubstance UI="C001277">geldanamycin</NameOfSubstance></Chemical></ChemicalList><CitationSubset>IM</CitationSubset><MeshHeadingList><MeshHeading><DescriptorName UI="D000730" MajorTopicYN="N">Androstadienes</DescriptorName><QualifierName UI="Q000494" MajorTopicYN="N">pharmacology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D000818" MajorTopicYN="N">Animals</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D017209" MajorTopicYN="N">Apoptosis</DescriptorName><QualifierName UI="Q000187" MajorTopicYN="N">drug effects</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D016227" MajorTopicYN="N">Benzoquinones</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D019703" MajorTopicYN="N">Calcineurin</DescriptorName><QualifierName UI="Q000378" MajorTopicYN="N">metabolism</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D002453" MajorTopicYN="N">Cell Cycle</DescriptorName><QualifierName UI="Q000187" MajorTopicYN="N">drug effects</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D016572" MajorTopicYN="N">Cyclosporine</DescriptorName><QualifierName UI="Q000494" MajorTopicYN="N">pharmacology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D004791" MajorTopicYN="N">Enzyme Inhibitors</DescriptorName><QualifierName UI="Q000494" MajorTopicYN="Y">pharmacology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D005658" MajorTopicYN="N">Fungi</DescriptorName><QualifierName UI="Q000187" MajorTopicYN="N">drug effects</QualifierName><QualifierName UI="Q000378" MajorTopicYN="N">metabolism</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D018841" MajorTopicYN="N">HSP90 Heat-Shock Proteins</DescriptorName><QualifierName UI="Q000187" MajorTopicYN="N">drug effects</QualifierName><QualifierName UI="Q000378" MajorTopicYN="N">metabolism</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D006801" MajorTopicYN="N">Humans</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D007166" MajorTopicYN="N">Immunosuppressive Agents</DescriptorName><QualifierName UI="Q000494" MajorTopicYN="Y">pharmacology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D047029" MajorTopicYN="N">Lactams, Macrocyclic</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D014176" MajorTopicYN="N">Protein Biosynthesis</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D011809" MajorTopicYN="N">Quinones</DescriptorName><QualifierName UI="Q000494" MajorTopicYN="N">pharmacology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D015398" MajorTopicYN="N">Signal Transduction</DescriptorName><QualifierName UI="Q000187" MajorTopicYN="Y">drug effects</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D020123" MajorTopicYN="N">Sirolimus</DescriptorName><QualifierName UI="Q000494" MajorTopicYN="N">pharmacology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D016559" MajorTopicYN="N">Tacrolimus</DescriptorName><QualifierName UI="Q000494" MajorTopicYN="N">pharmacology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D000077191" MajorTopicYN="N">Wortmannin</DescriptorName></MeshHeading></MeshHeadingList><NumberOfReferences>71</NumberOfReferences></MedlineCitation><PubmedData><History><PubMedPubDate PubStatus="pubmed"><Year>1998</Year><Month>11</Month><Day>10</Day></PubMedPubDate><PubMedPubDate PubStatus="medline"><Year>1998</Year><Month>11</Month><Day>10</Day><Hour>0</Hour><Minute>1</Minute></PubMedPubDate><PubMedPubDate PubStatus="entrez"><Year>1998</Year><Month>11</Month><Day>10</Day><Hour>0</Hour><Minute>0</Minute></PubMedPubDate></History><PublicationStatus>ppublish</PublicationStatus><ArticleIdList><ArticleId IdType="pubmed">9807840</ArticleId><ArticleId IdType="pii">S0167-7799(98)01239-6</ArticleId><ArticleId IdType="doi">10.1016/s0167-7799(98)01239-6</ArticleId></ArticleIdList></PubmedData></pubmed><affiliations><list><country><li>États-Unis</li></country><region><li>Caroline du Nord</li></region></list><tree><noCountry><name sortKey="Cutler, N S" sort="Cutler, N S" uniqKey="Cutler N" first="N S" last="Cutler">N S Cutler</name><name sortKey="Heitman, J" sort="Heitman, J" uniqKey="Heitman J" first="J" last="Heitman">J. Heitman</name><name sortKey="Sanfridson, A" sort="Sanfridson, A" uniqKey="Sanfridson A" first="A" last="Sanfridson">A. Sanfridson</name></noCountry><country name="États-Unis"><region name="Caroline du Nord"><name sortKey="Cardenas, M E" sort="Cardenas, M E" uniqKey="Cardenas M" first="M E" last="Cardenas">M E Cardenas</name></region></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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